Luc Dupuis Selected Research

Dynactin Complex

4/2015	Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration.
6/2011	Cytoplasmic dynein in neurodegeneration.
11/2010	A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
6/2007	Amyotrophic lateral sclerosis: all roads lead to Rome.

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Luc Dupuis Research Topics

Disease

37	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2021 - 02/2002
5	Atrophy 10/2021 - 11/2010
5	Disease Progression 01/2018 - 01/2013
5	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2015 - 06/2005
5	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2014 - 06/2007
3	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 03/2020 - 10/2010
3	Amyotrophic Lateral Sclerosis 8 11/2018 - 01/2013
3	Insulin Resistance 01/2018 - 01/2010
3	Parkinson Disease (Parkinson's Disease) 01/2018 - 06/2011
3	Huntington Disease (Huntington's Disease) 06/2011 - 11/2010
2	Respiratory Insufficiency (Respiratory Failure) 01/2018 - 01/2016
2	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 01/2016
2	Body Weight (Weight, Body) 04/2016 - 01/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2013 - 05/2013
2	Alzheimer Disease (Alzheimer's Disease) 06/2011 - 06/2005
2	Muscular Atrophy (Muscle Atrophy) 10/2010 - 04/2010
1	Weight Loss (Weight Reduction) 10/2021
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2021
1	Ataxia (Dyssynergia) 01/2021
1	Neuromuscular Diseases (Neuromuscular Disease) 03/2020
1	Muscular Diseases (Myopathy) 03/2020
1	Anemia 10/2018
1	Deglutition Disorders (Dysphagia) 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 01/2018
1	Spinal Cord Injuries (Spinal Cord Injury) 09/2017
1	Parkinsonian Disorders (Parkinsonism) 04/2015
1	Death (Near-Death Experience) 05/2014
1	Neuroinflammatory Diseases 05/2013
1	Multiple Sclerosis 01/2013
1	Obesity 09/2012
1	Dementia (Dementias) 03/2012
1	Cerebellar Ataxia (Dysmetria) 06/2011
1	Gliosis 11/2010
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2010
1	X-Linked Bulbo-Spinal Atrophy 10/2010
1	Ischemia 04/2010
1	Breast Neoplasms (Breast Cancer) 03/2010

Drug/Important Bio-Agent (IBA)

7	Dyneins (Dynein)IBA 04/2015 - 01/2009
4	LipidsIBA 10/2021 - 07/2007
4	Dynactin ComplexIBA 04/2015 - 06/2007
4	Superoxide Dismutase-1IBA 04/2010 - 02/2002
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021 - 01/2016
3	Riluzole FDA LinkGeneric 01/2018 - 03/2010
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 05/2013
3	Serotonin (5 Hydroxytryptamine)IBA 09/2017 - 10/2010
3	AdiponectinIBA 01/2017 - 01/2010
3	Prion ProteinsIBA 08/2003 - 02/2002
2	5-HT2B Serotonin ReceptorIBA 12/2021 - 03/2016
2	Peptides (Polypeptides)IBA 10/2021 - 04/2016
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2016
2	polyglutamineIBA 01/2021 - 10/2010
2	RNA-Binding Protein FUSIBA 01/2021 - 01/2021
2	RNA (Ribonucleic Acid)IBA 01/2021 - 05/2013
2	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 11/2018 - 06/2013
2	IgA receptor (protein B)IBA 11/2018 - 06/2013
2	LeptinIBA 01/2017 - 01/2010
2	AdipokinesIBA 01/2017 - 01/2010
2	Pioglitazone (Actos)FDA Link 04/2016 - 01/2012
2	Pharmaceutical PreparationsIBA 04/2016 - 03/2010
2	EnzymesIBA 04/2016 - 12/2003
2	Glucose (Dextrose)FDA LinkGeneric 09/2012 - 01/2010
2	AntioxidantsIBA 04/2010 - 12/2003
2	Proteins (Proteins, Gene)FDA Link 03/2010 - 06/2005
2	Protein Isoforms (Isoforms)IBA 04/2005 - 02/2002
1	CarbohydratesIBA 10/2021
1	Ataxin-2IBA 01/2021
1	PrionsIBA 03/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Cholinergic ReceptorsIBA 11/2019
1	DeferiproneIBA 10/2018
1	IronIBA 10/2018
1	Nuclear RNAIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 01/2018
1	Monoamine Oxidase (MAO)IBA 01/2018
1	Vitamin A (Retinol)FDA LinkGeneric 01/2018
1	rasagiline (Azilect)FDA Link 01/2018
1	Serotonin ReceptorsIBA 09/2017
1	C-Reactive ProteinIBA 01/2017
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 04/2016
1	MelanocortinsIBA 04/2016
1	FumaratesIBA 01/2013
1	LigandsIBA 01/2013
1	Insulin (Novolin)FDA Link 09/2012
1	ProgranulinsIBA 03/2012
1	Transcription Factors (Transcription Factor)IBA 01/2012
1	PPAR gammaIBA 01/2012
1	Cytoplasmic DyneinsIBA 01/2011
1	Huntingtin ProteinIBA 01/2011
1	Dopamine (Intropin)FDA LinkGeneric 11/2010
1	Androgen Receptors (Androgen Receptor)IBA 10/2010
1	tempolIBA 04/2010
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 03/2010
1	Granulocyte Colony-Stimulating Factor Receptors (G-CSF Receptor)IBA 02/2010
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2010

Therapy/Procedure

2	Therapeutics 01/2018 - 03/2010
2	Denervation 11/2006 - 11/2002
1	Enteral Nutrition (Feeding, Tube) 01/2015
1	Gastrostomy 01/2015
1	Tracheostomy 05/2014